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Tushar Kumeria      
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Tushar Kumeria published an article in December 2018.
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Amirali Popat

27 shared publications

School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia

Ranu Nayak

6 shared publications

Amity Institute of Nanotechnology, Amity Institute of Nano Technology, Noida, 201303, INDIA

John M. Mariadason

5 shared publications

Olivia Newton-John Cancer Research Institute, La Trobe University School of Cancer Medicine, Melbourne, VIC 3084, Australia

Naisarg Pujara

3 shared publications

School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia

Anand Kumar Meka

1 shared publications

School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia

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Distribution of Articles published per year 
(2018)
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Publications
Article 0 Reads 0 Citations Rapid Processing of Wafer-Scale Anti-Reflecting 3D Hierarchical Structures on Silicon and Its Templation Harsimran Singh Bindra, JaiKrishna R., Tushar Kumeria, Ranu ... Published: 18 December 2018
Materials, doi: 10.3390/ma11122586
DOI See at publisher website ABS Show/hide abstract
Hierarchically structured silicon (Si) surfaces with a combination of micro/nano-structures are highly explored for their unique surface and optical properties. In this context, we propose a rapid and facile electroless method to realize hierarchical structures on an entire Si wafer of 3″ diameter. The overall process takes only 65 s to complete, unlike any conventional wet chemical approach that often combines a wet anisotropic etching of (100) Si followed by a metal nanoparticle catalyst etching. Hierarchical surface texturing on Si demonstrates a broadband highly reduced reflectance with average R% ~ 2.7% within 300–1400 nm wavelength. The as-fabricated hierarchical structured Si was also templated on a thin transparent layer of Polydimethylsiloxane (PDMS) that further demonstrated prospects for improved solar encapsulation with high optical clarity and low reflectance (90% and 2.8%).
Article 0 Reads 0 Citations Enhanced Solubility, Permeability and Anticancer Activity of Vorinostat Using Tailored Mesoporous Silica Nanoparticles Anand Kumar Meka, Laura J. Jenkins, Mercedes Dàvalos-Salas, ... Published: 17 December 2018
Pharmaceutics, doi: 10.3390/pharmaceutics10040283
DOI See at publisher website ABS Show/hide abstract
Suberoylanilide hydroxamic acid (SAHA) or vorinostat (VOR) is a potent inhibitor of class I histone deacetylases (HDACs) that is approved for the treatment of cutaneous T-cell lymphoma. However, it has the intrinsic limitations of low water solubility and low permeability which reduces its clinical potential especially when given orally. Packaging of drugs within ordered mesoporous silica nanoparticles (MSNs) is an emerging strategy for increasing drug solubility and permeability of BCS (Biopharmaceutical Classification System) class II and IV drugs. In this study, we encapsulated vorinostat within MSNs modified with different functional groups, and assessed its solubility, permeability and anti-cancer efficacy in vitro. Compared to free drug, the solubility of vorinostat was enhanced 2.6-fold upon encapsulation in pristine MSNs (MCM-41-VOR). Solubility was further enhanced when MSNs were modified with silanes having amino (3.9 fold) or phosphonate (4.3 fold) terminal functional groups. Moreover, permeability of vorinostat into Caco-2 human colon cancer cells was significantly enhanced for MSN-based formulations, particularly MSNs modified with amino functional group (MCM-41-NH2-VOR) where it was enhanced ~4 fold. Compared to free drug, vorinostat encapsulated within amino-modified MSNs robustly induced histone hyperacetylation and expression of established histone deacetylase inhibitor (HDACi)-target genes, and induced extensive apoptosis in HCT116 colon cancer cells. Similar effects were observed on apoptosis induction in HH cutaneous T-cell lymphoma cells. Thus, encapsulation of the BCS class IV molecule vorinostat within MSNs represents an effective strategy for improving its solubility, permeability and anti-tumour activity.
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