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Wolgang Arnold   Professor  Senior Scientist or Principal Investigator 
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Wolgang Arnold published an article in January 2019.
Top co-authors See all
Oliver Schildgen

116 shared publications

Dipl.-Biologe, Fachvirologe GfV Institut für Pathologie, Kliniken der Stadt Köln gGmbH, Klinikum der Privaten Universität Witten/Herdecke, Ostmerheimer Str. 200, D-51109 Cologne, Germany

Gholamreza Danesh

25 shared publications

Universität Witten, Witten, Germany

P. Gaengler

25 shared publications

ORMED Institute for Oral Medicine at the University of Witten/Herdecke, Witten, Germany

Monika Pieper

17 shared publications

Kliniken der Stadt Köln gGmbH, Institut für Pathologie, Kliniken der Privaten Universität Witten/Herdecke mit Sitz in Köln, Ostmerheimer Str. 200, D-51109 Köln/Cologne, Germany

Ella A. Naumova

15 shared publications

Department of Biological and Material Sciences in Dentistry, School of Dentistry, Faculty of Health, Witten/Herdecke University, Alfred-Herrhausen-Strasse 44, 58455 Witten, Germany

Publication Record
Distribution of Articles published per year 
(2009 - 2019)
Total number of journals
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Publications See all
Article 0 Reads 0 Citations Bacterial viability in oral biofilm after tooth brushing with amine fluoride or sodium fluoride E.A. Naumova, L. Weber, V. Pankratz, V. Czenskowski, W.H. Ar... Published: 01 January 2019
Archives of Oral Biology, doi: 10.1016/j.archoralbio.2018.10.013
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The aim of this study was to investigate the effects of sodium fluoride (NaF) and amine fluoride (AmF) on bacterial viability in the oral cavity. Healthy subjects brushed their teeth with either fluoride free toothpaste, NaF- or AmF-containing toothpaste. Biofilm smears from different locations were collected before and immediately and 30 and 120 minutes after tooth brushing. The smears were stained with live/dead bacterial staining, and the number of the respective bacteria was counted. The data were statistically analyzed by comparing the numbers of bacteria before and after the application of no fluoride, NaF and AmF. The highest numbers of bacteria were found in the tongue biofilm, followed by the palatal and cheek biofilm. The lowest numbers were found in the mouth floor biofilm. After the application of AmF, no changes in the numbers of bacteria were found in the biofilms, except for the cheek, where they were reduced. After the application of NaF, the number of bacteria decreased significantly in all biofilms. After 120 minutes, bacterial regrowth was complete. AmF has only little effect on the bacterial viability of oral biofilms. NaF application reduces the number of living bacteria in the oral biofilms. This effect lasts not longer than 120 minutes.
Article 0 Reads 0 Citations Human Bocavirus Infection of Permanent Cells Differentiated to Air-Liquid Interface Cultures Activates Transcription of ... Verena Schildgen, Monika Pieper, Soumaya Khalfaoui, Wolfgang... Published: 30 October 2018
Cancers, doi: 10.3390/cancers10110410
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The parvoviral human bocavirus (HBoV) is a respiratory pathogen, able to persist in infected cells. The viral DNA has been identified in colorectal and lung tumors and thus it was postulated that the virus could be associated with tumorigenesis. This assumption was supported by the fact that in HBoV-infected patients and in an in vitro cell culture system, pro-cancerogenic and -fibrotic cytokines were expressed. In this work, it is shown by a whole transcriptome analysis that, also at the mRNA level, several pathways leading to neoplasia and tumorigenesis are significantly upregulated. In total, a set of 54 transcripts are specifically regulated by HBoV, of which the majority affects canonical pathways that may lead to tumor development if they become deregulated. Moreover, pathways leading to necrosis, apoptosis and cell death are downregulated, supporting the hypothesis that HBoV might contribute to the development of some kinds of cancer.
Article 2 Reads 0 Citations Influence of Luting Materials on the Retention of Cemented Implant-Supported Crowns: An In Vitro Study Ella A. Naumova, Felix Roth, Berit Geis, Christine Baulig, W... Published: 28 September 2018
Materials, doi: 10.3390/ma11101853
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The retention force of cemented crowns on implant abutments with various luting materials was evaluated. Cobalt–chromium crowns were cemented onto tapered titanium abutments (Camlog) with eugenol-free temporary cement (RelyX TempBond NE), composite-based temporary cement (Bifix Temp), zinc phosphate cement (Harvard Cement), glass-ionomer cements (Meron, Fuji I), and resin-modified glass-ionomer cements (Fuji II, Fuji Plus, Ketac Cem Plus). Specimen aging via hydrostress was performed in artificial saliva at 37 °C for 14 days (S1), followed by hydrothermal stress with thermocycling (S2). The crowns were removed, and the force was recorded (T1). Subsequently, the crowns were recemented, aged, and removed, and the force was recorded (T2, T3). The retention forces differences were statistically significant according to the storage conditions at T1 (p = 0.002) and T3 (p = 0.0002). After aging (S1), Ketac Cem Plus had the highest retention force median value difference (T3 versus T1) (−773 N), whereas RelyX TempBond NE had the lowest (−146 N). After aging (S2), Meron had the highest retention force median value difference (−783 N), whereas RelyX TempBond NE had the lowest (−168 N). Recementation decreased the retention force of the implant-supported cobalt–chromium crowns cemented and recemented with the same luting materials. Luting materials (at T1) and aging conditions significantly impacted the retention force.
Article 0 Reads 1 Citation Parallel study about the effects of psychotherapy on patients with dental phobia determined by anxiety scores and saliva... E. A. Naumova, S. Faber, A. Wannemueller., T. Sandulescu, P.... Published: 02 August 2016
BMC Oral Health, doi: 10.1186/s12903-016-0264-2
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Background The aim of this study was to determine the success of psychotherapeutic treatment for dental phobia by measurement of anxiety using the dental anxiety score (DAS), the state trait anxiety score (STAI state), salivary cortisol and protein concentrations and the salivary secretion rate. Primary endpoint of the study was the comparison of the data before and after psychotherapeutic treatment. Methods Forty patients were included into the study. Twenty-four were allocated to the phobic group, 16 to the control group. Saliva was collected upon entering the dental clinic and again after three weeks of psychotherapy. The results were compared with those of a control group. The DAS and STAI questionnaires were completed at each visit. Results A reduction in DAS values was found after psychotherapy. However, the values remained significantly higher in the phobic group than in the controls. Similar results were found for STAI scores. A slightly higher salivary cortisol level was found in the phobic group. No changes occurred in cortisol or protein concentrations. The salivary secretion rate increased in the phobic patients after psychotherapy. Conclusions It could be concluded that psychotherapy is effective in the treatment of dental phobic patients. Trial registration This study has been retrospectively registered in the German Clinical Trials Register (# DRKS00009552) on 10/19/15. Keywords Dental phobia Salivary cortisol Salivary protein Dental anxiety score State trait anxiety score Psychotherapy
BOOK-CHAPTER 0 Reads 0 Citations Cervical Erosions: Morphology and Restoration of Cervical Erosions Wolfgang H. Arnold Published: 17 June 2016
Understanding Dental Caries, doi: 10.1007/978-3-319-30552-3_13
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Article 0 Reads 2 Citations Dentin abrasivity of various desensitizing toothpastes W. H. Arnold, Ch. Gröger, M. Bizhang, E. A. Naumova Published: 02 April 2016
Head & Face Medicine, doi: 10.1186/s13005-016-0113-1
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Background The aim of this study was to compare the abrasivity of various commercially available toothpastes that claim to reduce dentin hypersensitivity. Methods Dentin discs were prepared from 70 human extracted molars. The discs were etched with lemon juice for 5 min, and one half of the discs were covered with aluminum tape. Following this, they were brushed with 6 different toothpastes, simulating a total brushing time of 6 months. As a negative control, discs were brushed with tap water only. The toothpastes contained pro-arginine and calcium carbonate, strontium acetate, stannous fluoride, zinc carbonate and hydroxyapatite, new silica, or tetrapotassium pyrophosphate and hydroxyapatite. After brushing, the height differences between the control halves and the brushed halves were determined with a profilometer and statistically compared using a Mann–Whitney U test for independent variables. Results A significant difference (p < 0.001) in height difference between the controls and the toothpaste-treated samples was found in all cases, except for the stannous fluoride-containing toothpaste (p = 0.583). The highest abrasion was found in the toothpaste containing zinc carbonate and hydroxyapatite, and the lowest was found in the toothpaste containing pro-arginine and calcium carbonate. Conclusions Desensitizing toothpastes with different desensitizing ingredients have different levels of abrasivity, which may have a negative effect on their desensitizing abilities over a long period of time. Keywords Toothpaste Dentin Dentin tubules Root dentin Hypersensitivity